Clarifying the Optimal Application of SLT Therapy Trial (COAST)
Clarifying the Optimal Application of SLT Therapy Trial (COAST)
Brief Summary:
The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or delay the need for daily eye drop medications better than waiting for SLT to wear off before repeating it.
Study Type: Interventional (Clinical Trial)
Estimated Enrollment: 640 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Subjects are randomized twice: the first, at study entry, to low energy or standard SLT; and the second, at Month 12, to annual or as-needed repeat SLT. There are 2 arms in the first 12 months of the study and 2 different arms in Months 13-48.
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Clarifying the Optimal Application of SLT Therapy Trial
Estimated Study Start Date: September 2021
Estimated Primary Completion Date: June 2027
Estimated Study Completion Date: August 2027
Arm:
- Experimental: First Randomization: Low Energy SLT
- Active Comparator: First Randomization: Standard Energy SLT
- Experimental: Second Randomization: Annual Low Energy Repeat SLT
- Active Comparator: Second Randomization: As-Needed Repeat SLT at Initial Energy
| Category | Value |
|---|---|
| Study type(s) | Interventional |
| Estimated enrolment | 640 |
| Estimated Study start date | 01 September 2021 |
| Estimated Study Completion Date | 01 August 2027 |