PH1 overview

Primary hyperoxaluria type 1 (PH1) is a life-limiting disease of oxalate overproduction, in which patients can present with a wide spectrum of clinical manifestations, from kidney stones to end-stage kidney disease (ESKD) to oxalate deposition in the eyes, heart and skin^1,2. Early intervention is imperative and this resource will detail the pathophysiology of PH1, offer typical patient presentations and give a review of current management options.