Journal

Alpha 1-Antitrypsin Deficiency

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Published:8th Apr 2020

Author: Strnad P, McElvaney NG, Lomas DA.

Source: The New England Journal of Medicine

Availability: Pay for access, or by subscription

Ref.:N Engl J Med. 2020 Apr 9;382(15):1443-1455.

DOI:10.1056/NEJMra1910234

Alpha 1-Antitrypsin Deficiency

AAT is a protease inhibitor targeting neutrophil elastase. It prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT deficiency is a genetic disorder characterized by pulmonary disease, especially emphysema and bronchiectasis, and hepatic disease.

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