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Role of Interleukin-22 in ulcerative colitis

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Published:1st Mar 2023

Author: Zhao N, Liu C, Li N, Zhou S, Guo Y, Yang S, et al.

Source: Biomedicine & Pharmacotherapy

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Ref.:Biomed Pharmacother. 2023 Mar;159:114273.

DOI:10.1016/j.biopha.2023.114273

Role of Interleukin-22 in ulcerative colitis

Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regeneration, while it can also induce inflammatory reactions when it is chronically overexpressed. Extensive literatures reported that IL-22 played an essential role in the pathogenic development of UC. IL-22 participates in the whole disease process of UC involving signaling pathways, gene expression regulation, and intestinal flora imbalance, making IL-22 a possible candidate for the treatment of UC. In this paper, the latest knowledge to further elucidate the role of IL-22 in UC was summarized and analyzed.

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