Positive results from clinical trial with Bentrio in house dust mite allergy is published in Clinical and Translational Allergy

The peer-reviewed article was published in Clinical and Translational Allergy, one of the leading journals in the field of allergology

The HDM trial enrolled 37 patients in Canada with a history of perennial allergic rhinitis ("PAR") who underwent controlled allergen exposure three times in a challenge chamber for three hours each. They were randomly assigned in an open label crossover design to receive either Bentrio in a single or double dose, or no treatment, prior to allergen exposure. The primary endpoint was the change in the Total Nasal Symptom Score (TNSS; determined in 20-minute intervals) from baseline. The ANCOVA (analysis of covariance) model demonstrated that Bentrio treatment reduced the increase in mean TNSS during the 3-hour exposure by 1.1 points (-1.87 to -0.28 in the 95% confidence interval; p<0.01) vs. no treatment. under bentrio treatment, the mean tnss was 4.1 points vs. 5.2 points under no treatment. administering two sprays rather than one puff did not yield any additional treatment benefits, confirming that a single application provides ample protection. a significant majority (86%) of study participants rated global tolerability of the treatment as good or very good.

“The positive results from the house dust mite challenge study nicely complement those from the grass pollen study, demonstrating significant protective effects regardless of the type of inhaled allergen particles,” commented Thomas Meyer, Altamira Therapeutics’ founder, Chairman and CEO. “Also, in both studies Bentrio exhibited a lasting protective effect for several hours, reflecting its long nasal residence time. As demonstrated in a previously published study, Bentrio provides a protective film on the nasal mucosa for about 3.5 hours which far exceeds the residence time of saline nasal spray, the current standard-of-care in drug-free allergic rhinitis management.”

See-"Barrier-forming, drug-free nasal spray reduces allergic symptoms induced by house dust mite allergen".Patricia Couroux, Nicole Grosse, Anne Marie Salapatek, Yasmeen Goyal, Oliver Pfaar, Ilja P. Hohenfeld. Clinical and Translational Allergy Volume 13, Issue 7. First published: 13 July 2023.